Araceli
Endeavor^®

High-content imaging (HCI) images cells in situ, preserving morphology and subcellular localization that flow cytometry loses after dissociation. Compared with confocal, plate-based widefield HCI delivers full-well coverage across 96/384/1536 plates in minutes, giving stronger statistics without the slower, small-FOV trade-offs of point-scanning (reserve confocal for thick 3D). For 2D screens, HCI’s even monolayers and clean segmentation enable rapid design→image→analyze cycles, multiplexed readouts, and reliable detection of subtle or rare phenotypes. And when you need depth, widefield HCI can capture 3D Z-stacks often paired with deconvolution to analyze compact spheroids or thin organoid sections while retaining high throughput.

Yes. Modern HCI can capture Z-stacks in both widefield and confocal modes, but 3D adds time, data size, and analysis complexity. For new teams, it’s smart to optimize the assay in 2D first, then move to small 3D pilots. Widefield 3D is a practical on-ramp: it’s fast and high-throughput, gentler on live samples (lower light dose), and easy to run in plates; with computational deconvolution you can suppress out-of-focus blur and recover crisp structures in compact spheroids or thin organoid sections. Confocal 3D provides true optical sectioning with stronger background rejection in thicker specimens, ideal when you need precise localization through depth—at the cost of slower acquisition and lower throughput. On Araceli Endeavor™ Ultra, even 3D stacks benefit from the instrument’s ultra-fast acquisition, letting you capture confirmatory Z-stacks across many wells quickly to maintain screening cadence and minimize time out of the incubator.

Acquisition & control: Every Endeavor system ships with EndeavorOS, the instrument’s intuitive acquisition software used across the portfolio for fast, full-plate imaging.

Real-time feedback during runs: Endeavor Ultra comes with ClaireRT™ which monitors assays as you image (e.g., focus/cell-count issues), helping you catch problems early and reduce reruns.

Post-acquisition analysis: Clairvoyance™ provides AI-powered image analysis, segmentation, feature extraction, and data visualization with video tutorials for users of all experience levels. Every Endeavor system ships with Clairvoyance.

Open-ecosystem compatibility: If you already use tools like CellProfiler, Endeavor images and metadata can be analyzed in those pipelines as well.

Very easy. Our software is designed to be intuitive, so most users can run plates confidently on day one. We typically schedule 1.5 days of training so we can tailor sessions to your specific applications.

Training plan (1.5 days)

Hands-on setup in EndeavorOS™: plate maps, channels, Z-stacks, laser autofocus, and running test plates.

Application-specific session with our Field Application Scientist (FAS): assay tuning, segmentation/metrics in Clairvoyance™, and data management best practices.

After training: You’ll have access to Clairvoyance quick-start videos, ≤24-hour phone/email support, secure remote assistance for rapid issue resolution, and optional refresher sessions for new hires.

Regional reach & support: Access to Araceli’s team of applications scientists and field service engineers span across the USA and Europe.

Fast response: We respond to service inquiries by phone or email within 24 hours. Most issues are resolved remotely via secure access to the instrument/workstation avoiding on-site delays. When a visit is needed, we strive to be on-site within 5 business days.

Warranty & coverage: Every system includes a 1-year manufacturer’s warranty. Extended Warranty & Service Plans (Optional): Extend coverage beyond year one with hardware protection for the equipment, and peripherals (parts, labor, and on-site dispatch when remote resolution isn’t possible), plus scheduled preventive maintenance and continued software updates for Endeavor and Clairvoyance. You also get priority support with responses within 24 hours and remote diagnostics. We strive to be on-site within 5 business days when needed.

Onboarding & training: Installation and hand-off training, plus application-focused sessions on EndeavorOS™ (acquisition), ClaireRT™ (real-time feedback), and Clairvoyance™ (analysis) available on-site or remote.

Ongoing resources: Software updates, how-to guides, application notes, and optional consulting for assay optimization/automation. Quickstart guide videos are available for Clairvoyance™ to help new users get productive fast.

Yes. We offer multiple demo options: we can send you an Araceli box with a return label so you can prepare and ship plates from your lab; we will image them in our Portland, OR demo facility, host a live remote demo using your plates, and provide a detailed results report. We also operate regional demo sites in Oregon, California and Boston, and Europe. To choose the best path for your location and explore on-site demo availability please reach out to your regional Business Development Manager via our Meet the Team page or submit an inquiry through Contact Us page.

Yes. Araceli systems are automation-ready through SiLA 2.0 for standardized device control/status, so schedulers and integrators can launch protocols, monitor runs, and exchange metadata reliably.

Yes, especially on Endeavor. Three things make it strong for rare events:

Maximum-well coverage at sub-micron resolution: capturing every cell instead of a few fields minimizes sampling bias Endeavor maintains ~0.27 µm/pixel while increasing coverage.

Throughput = statistical power: image entire 96/384/1536-well plates in minutes, surveying millions of cells so rare phenotypes aren’t missed; example: a full-plate genotoxicity run segmented ~892k nuclei and detected ~10.8M spots.

QC and analytics built-in: ClaireRT™ flags focus/assay issues during acquisition to avoid reruns, while Clairvoyance™ performs sensitive spot counting, localization, and phenotype profiling on high-resolution data.

By pairing complete sample coverage, fast plate-scale imaging, and robust QC/analysis, Endeavor makes rare cell detection practical and reliable in routine screening.

A proprietary laser autofocus achieves ultra-fast focusing with no user adjustment required (optional Z-offset available for samples outside the main focal plane).

Expect ~58.1 GB per channel per plate at full res, regardless of plate density (96/384/1536 wells).

Endeavor Ultra’s instrument footprint is ~28″ W × 26″ D × 26″ H (~71 × 63.5 × 66 cm) and ~245 lb (108 kg). Recommended clearances: 12.25″ (31 cm) on each side, 8.25″ (21 cm) behind, and 24″ (61 cm) above; additional service access requires ~23.6″ (60 cm) on the sides and ~11.8″ (30 cm) behind. Operate in 15–30 °C and 35–50% RH in a low-vibration, low-dust environment. Use a rollable, low-vibration table (anti-vibration preferred).

Exact capacity depends on your assay mix (plates/day, channels, bit depth, well coverage), retention policy and anticipated throughput. With Endeavor platforms plan for a fast “ingest” tier on-prem plus expandable long-term storage.

Endeavor Ultra: As a starting point, we recommend an on-site NAS with ~80 TB of SSD (expandable to ~159 TB) on a 100 GbE link for rapid off-load from Endeavor;

Endeavor Pro & Core: We also offer a ~106 TB platter-based drive NAS option on 25 GbE when ultra-high I/O isn’t required. Both options are designed to keep up with Endeavor’s image size and speed.

Clairvoyance™ analysis workstation, sold separately comes with a 2 TB local storage.